Twilight fans were the first to get a surprise treat when the cast joined the fans who have been waiting in line for, in some instances, over three days. Kristen Stewart, Robert Pattinson and Taylor Lautner later attended a panel to talk about the vampire franchise's final movie.
Copyright: FoxUS TV stars from shows such as The Big Bang Theory, Game of Thrones and Glee will be heading to San Diego later this week along with a few Brits such as the Doctor Who cast.
Stick with Digital Spy all weekend for fresh pictures of the stars arriving at the pop culture fan-fest.
San Diego's Comic-Con runs from July 11 to 15.
> Full Comic-Con coverage
Watch our video with the hardcore Twilight fans at Comic-Con below: