Ricky Gervais, Joan Rivers, Dane Cook and Chris Rock have appeared on the FX series in the past and Louis CK recently teased that "four Oscar winners" cameo in the new season.
In an interview with Collider, the comic shed more light on his celebrity guest stars.
"I got a lot of great people this year. I won't tell you all of them, but Melissa Leo is in the second episode," Louis CK revealed. "F Murray Abraham comes back. He's one of my favourite guys, ever. Robin Williams does a thing on the show, later in the season. Jerry Seinfeld is on the show."
He added: "There are a lot of guest stars that are piling up, and I'm excited about it."
Louis CK went on to reveal how he got Oscar winner Leo to shoot a cameo appearance on a recent instalment.
"I love Melissa Leo, very much, as an actor, so she was in my head. When I wrote the thing that she's in, I wrote it, in my head, for the kind of women I knew in Boston, growing up, and then it just hit me that Melissa Leo would be amazing," he recalled.
"It was very simple. We sent it to her reps and, in a few days, she said yes. She just really responded to the material, and she showed up and took it very seriously."
Louis CK further explained: "[Melissa] really approached it the way I wanted her to, as an actress. On my show, there's not really a comedy muscle you have to use. We play most of the scenes real and straight for comedy.
"Our eyebrows don't all go up, like they do on most sitcoms. So, somebody like her is perfect for my show."
The critically-acclaimed Louie airs Thursdays at 10.30pm ET on FX.
Watch a Louie season three preview below: