The late night host will celebrate his best musical parodies and collaborations during the NBC show.
Fallon will perform his parody hits including his Tim Tebow/David Bowie mash-up, as well as his impersonation of Neil Young as he sings the Fresh Prince of Bel-Air television theme song.
He will also recap his musical collaborations with some of the biggest artists today such as Justin Timberlake, Sir Paul McCartney and Bruce Springsteen.
Last month, Fallon released the album Blow Your Pants Off, featuring his famous Late Night collaborations and new original songs.
Fallon's primetime special will be broadcast on Wednesday, July 25 at 10pm ET on NBC.
Watch Jimmy Fallon as Neil Young below: