Potente will appear in the upcoming second season as a "mysterious patient" at the asylum headed by Jessica Lange's character, reports TVLine.
She joins previously announced cast members Mark Consuelos, Clea Duvall, Adam Levine, Chloe Sevigny, Zachary Quinto and Joseph Fiennes.
Prior to Potente's casting news, Jenna Dewan was revealed to be playing Levine's love interest on the series.
Dewan is the wife of Magic Mike star Channing Tatum; the couple starred together in 2006 dance movie Step Up.
Potente is best known for her role in 1998 action thriller Run Lola Run. Since then, she has appeared in films such as Blow and the three Jason Bourne films.
Watch the trailer for American Horror Story's first season below: