The USA series centers on a divorcee who gets a job as a therapist for the football team New York Hawks.
Cuban, who owns NBA team Dallas Mavericks, will play a potential owner of the Hawks who has hidden motives, reports Entertainment Weekly.
In December 2011, Los Angeles Lakers player Lamar Odom was traded to the Mavericks, but was let go from the team in April.
Odom said: "The Mavericks and I have mutually agreed that it's in the best interest of both parties for me to step away from the team."
Odom won the NBA Finals twice while playing for the Lakers. He is married to Khloe Kardashian.
Watch a trailer for Necessary Roughness below: