The Jackson family member will front Life with La Toya on Oprah Winfrey's OWN.
The show will follow Jackson as she deals with her famous family and her entertainment business empire.
"I am so pleased to be working with television legend Oprah Winfrey and to be a part of the OWN family," Jackson said. "This will be one of the most exciting adventures of my life."
OWN co-president Sheri Salata added that the series has been developed for months, saying: "We are delighted to work with La Toya to bring this new show to OWN viewers."
It will be produced by World of Wonder with Ja-Tail Television, and will premiere in 2013. Jackson will executive produce along with Fenton Bailey, Randy Barbato, Jeffré Phillips and Charles Cook.
Bailey and Barbato previously produced the Chaz Bono documentary Becoming Chaz.
La Toya Jackson recently urged family members to end their ongoing feud relating to her late brother Michael Jackson's will.