The popular sitcom has aired five seasons on CBS, with a sixth due to premiere on September 27 and a seventh already ordered.
"You don't want to repeat yourself," Lorre explained to Deadline. "After 100-some-odd episodes, redundancy is looming."
Lorre also argued that the show's success - including February's ratings high of 16.54m viewers - does not make it any easier to produce The Big Bang Theory.
"That has nothing to do with what you do every day - just to try and find a good story and execute it," he insisted.
The stars of The Big Bang Theory recently spoke to Digital Spy about the show's future, with Kaley Cuoco (Penny) admitting that she wants the show to run for ten years in total.
"I'd like to reach the big ten - I think that would be amazing," she said. "If people want to keep watching us, I can see no reason why it wouldn't happen."
The Big Bang Theory airs on CBS in the US. In the UK, the series is broadcast by Channel 4 and E4.
> Big Bang Theory stars on Penny, Leonard future: 'They need to mature'
> Big Bang Theory stars on season six, Howard's wedding - video
Watch the Big Bang Theory cast discuss the show's future below: