The sitcom - written by Hank Nelken - follows the lives of an average man and his genius wife, Deadline reports.
Hit by financial troubles, the couple are forced to move in with her family, who are equally intelligent but socially inept and emotionally stunted.
Nelken's past writing credits include 2001 Jason Biggs film comedy Saving Silverman - known as Evil Woman outside of North America - and Ice Cube movie Are We Done Yet?.
America's Funniest Home Videos creator Vin Di Bona will executive produce the Dumb F**k pilot, alongside Bruce Gersh, Susan Levison and Shaleen Desai.
Other pilots in development for ABC's 2013-14 television season include a Romeo & Juliet update from producer McG (This Means War) and an Incredible Hulk adaptation.
> Marvel, ABC team on Avengers television show
> Ringer creators developing 'gothic thriller' series for NBC
Watch the trailer for Saving Silverman below: