The daytime series has featured guest co-hosts including Martin Short, Nick Lachey and Donald Trump since Regis Philbin departed the show in November 2011.
Producers have now announced that Ripa will host Live! solo for the very first time on September 3, before unveiling her new on-air partner the next day (September 4).
Ripa and her new co-host will interview Homeland star Claire Danes and American Idol winner Phillip Phillips on their first episode together.
The presenter has said in the past that she would like Anderson Cooper to be her permanent co-host, but Cooper currently has two other series on the air.
Seth Meyers was also rumoured to be in the running for the job at one point. He has since responded that he plans to return to Saturday Night Live for another season.
Ripa has served as one of Live!'s co-hosts since 2001.