George's band are pitted against One Direction, Frank Ocean, fun. and Carly Rae Jepsen in the 'Best New Artist' category. The award has previously been won by Eurythmics, Guns N' Roses, Nirvana and Justin Bieber.
In an interview with The AP, George joked that The Wanted are unlikely to join the prestigious group of 'Best New Artist' winners.
"I think One Direction will win. That is my prediction," he said.
George's bandmate Tom Parker appeared more optimistic, insisting that The Wanted still have a shot to take the prize.
"We could win 'Best New Artist', come on! We are one of the best new artists," Parker declared to his bandmates, adding: "We can take Frank Ocean. We can do this, boys!"
Kevin Hart hosts the upcoming VMAs ceremony, featuring live performances by Green Day, Taylor Swift, Rihanna, Alicia Keys, Pink and One Direction.
The 2012 MTV Video Music Awards airs live from the Staples Centre in Los Angeles on Thursday, September 6 at 8/7c.
> MTV Video Music Awards 2012: The nominees in full
Watch The Wanted's 'Glad You Came' music video below