Tom Hanks, Halle Berry, Olympians Missy Franklin and Gabby Douglas, Ray Romano and Felicity Huffman are also slated to appear in appeals on Friday's telethon.
Stand Up to Cancer is to air simultaneously on ABC, CBS, Fox, NBC and various cable channels and will be produced by Joel Gallen and Gwyneth Paltrow.
Paltrow previously lined up celebrity presenters Katie Couric, Julia Roberts, The Avengers stars Samuel L Jackson and Jeremy Renner, Rashida Jones, Matt Damon and Jessica Biel.
Coldplay, Taylor Swift, Alicia Keys and Tim McGraw are all expected to perform on the fundraising broadcast.
The third Stand Up to Cancer telethon airs Friday, September 7 at 8/7c.
Watch a promo for Stand Up to Cancer below