Poehler, Adam Scott, Chris Pratt, Aubrey Plaza, Aziz Ansari and Parks and Recreation co-creator Mike Schur are all scheduled to take part in the video chat.
The event will stream live on Google Play from 4pm ET.
Fans without Google+ profiles will be required to set up an account in order to submit questions to the Parks and Recreation cast.
Parks and Recreation returns to NBC with a 22-episode fifth season on Thursday, September 20 on NBC.
Xena and Battlestar Galactica's Lucy Lawless is to guest star on the new season as love interest for Ron Swanson (Nick Offerman).