The series, created by Glee's Ryan Murphy, has sparked anti-gay protests in the US, with NBC's Utah affiliate KSL-TV refusing to air the series.
"You know, I don't understand that [KSL-TV decision] at all," Blair - who plays Clay Clemmens - told Entertainment Weekly.
The New Normal follows a gay couple who decide to have a baby via a surrogate, but Blair argued that the broader theme of the show is "two families coming together".
"The show isn't [just] about a gay couple," he explained. "It's about two families coming together to create this new normal. It's a great story, and it's got so many important issues that people struggle with and deal with today.
"I wish [critics] would look past [its gay content]. I hope that they do."
Blair's co-stars Ellen Barkin and and Georgia King have also defended The New Normal, with the former insisting that the series is not "offensive" and the latter encouraging people to watch the show "before [they] judge it".
> Ryan Murphy's The New Normal gets Utah station after KSL-TV refusal
The New Normal premieres on NBC on Tuesday, September 11 at 9.30/8.30c. E4 will air the series in the UK.
Watch a trailer for The New Normal below: