This week's musical guest Frank Ocean confirmed that Mayer will be joining him on SNL in a Twitter post on Tuesday (September 11).
"SNL this weekend. Me and the bro John Mayer," Ocean wrote.
Mayer and Ocean are expected to perform the track 'White', but that has yet to be confirmed.
NBC announced three additions to Saturday Night Live's cast this week, with Aidy Bryant, Tim Robinson and Cecily Strong becoming featured players.
Seth MacFarlane hosts Saturday Night Live's season 38 premiere, airing at 11.30 ET on NBC.
Listen to Frank Ocean and John Mayer's song 'White' below: