The untitled project has been granted a script order by the Peacock Network, according to The Hollywood Reporter.
DeGeneres will collaborate with Lauren Pomerantz - a writer and producer for her daytime talkshow Ellen - on the comedy.
Pomerantz will write and act as an executive producer on the Warner Bros Television show.
The show's protagonist reportedly becomes convinced that she will die alone as she dwells on paperwork for a house purchase which lists her as a "single woman", and she turns to those around her - from friends and family to a therapist - as she seeks to justify her decision.
DeGeneres was recently honoured with a star on the Hollywood Walk of Fame.