The Step Up actress will play one of star Julia Ormond's daughters, struggling to keep her supernatural powers a secret.
According to TVLine, Dewan will play Freya Beauchamp, a free spirit who settles down with her millionaire fiancé Dash Gardiner in the secluded Long Island town of North Hampton.
A series of events forces Ormond's character to reveal to her two adult daughters that they are in fact powerful, immortal witches.
The pilot is based on the best-selling novel by Melissa de la Cruz, and written by Eastwick creator Maggie Friedman.
The hour-long pilot for Witches of East End is expected to air later this year.
Jenna Dewan will next be seen on television in the upcoming season of American Horror Story.