Daniel Tosh's viral video comedy show will return with 30 episodes after its current fourth season comes to an end.
The fifth season will debut on the network in January 2013.
Tosh.0 has become Comedy Central's most-watched show since it launched in 2009, with the fourth season premiere giving the network a record 4.1 in the coveted 18-49 demo ratings.
"Despite the fact that Tosh.0 has more viewers than any other show on our network, and that Daniel has totally catalysed his fans online, we still convinced ourselves to pick up the show for another season," said Comedy Central head of original programming and production Kent Alterman.
Daniel Tosh joked: "It's hard for me to get excited about anything when the Miami Dolphins look so terrible."
Tosh.0's fourth season continues on Tuesday, September 25.