The German actress will make her leading US TV show debut in The Bridge.
The drama will be directed by Mexican filmmaker Gerardo Naranjo.
The Bridge is adapted from the Scandinavian drama series Bron/Broen, and follows two detectives from the US and Mexico - El Paso Police Homicide Detective Sonya North (Kruger) and Marco Ruiz.
The pair must join forces to find a serial killer who murders people on both sides of the border.
The show has been adapted for US TV by Homeland's Meredith Stiehm and Hawaii Five-0's Elwood Reid.
Diane Kruger has previously starred in a number of big screen successes, including Quentin Tarantino's Inglourious Basterds, Troy and the National Treasure franchise.
On US TV screens she has previously appeared in an episode of Fringe alongside her current boyfriend Joshua Jackson.
She will play Abraham Lincoln's stepmother in Green Blade Rising.