Simon - who recently announced plans to wrap up his HBO drama Treme - told Entertainment Weekly that he found working in series television "exhausting".
"I'm re-evaluating what the future holds in terms of episodic television on a personal level," he explained. "These things are exhausting to undertake. You gotta be completely committed to a long journey."
Simon also praised HBO's commitment to "pure story", explaining that his former show The Wire was almost cancelled on more than one occasion due to falling ratings.
"The Wire was cancelled after season three, and The Wire was nearly cancelled again - I had to grovel and beg and plead - after season four," he admitted. "To their great credit, HBO listened, and on the argument of story – not anything else because we didn't have an audience – on the argument of story, let us finish.
"This is not a new dynamic. I've been living with this for the last 6-7 years. It just is what it is."
The third season of David Simon's Treme currently airs on HBO on Sundays. The series airs on Sky Atlantic in the UK.
> The Wire creator David Simon apologises for calling fans "wearying"
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Watch a clip from the new season of Treme below: