The R&B star will appear in four episodes of the new series, which will air on the TLC network in the US.
Totally T-Boz will air on the network in 2013, TMZ reports.
The show's announcement arrives less than a year after Watkins filed for bankruptcy in November 2011.
Totally T-Boz will centre on the 42-year-old as she attempts to relaunch her music career, while also working as a single mother.
She has also been recovering from a brain tumour that was first diagnosed in 2006. She later struggled with walking and speaking since it was removed.
The series will also star her family members including her daughter, brother, cousins and other friends.
It is currently filming in Atlanta for broadcast next year.
TLC announced plans for a comeback tour featuring a hologram of late bandmate Lisa 'Left-Eye' Lopes back in April.