Rose will consent to a rare live interview on Jimmy Kimmel's late-night talkshow on October 24, reports Rolling Stone.
The 'Welcome to the Jungle' singer is appearing on Jimmy Kimmel Live to promote Guns N' Roses' residency at the Hard Rock Hotel & Casino in Las Vegas.
Guns N' Roses kick off their Las Vegas concert series on Halloween (October 31) and will remain at the venue through November 24.
Rose has shunned the spotlight in recent years, even declining to attend Guns N' Roses' induction into the Rock and Roll Hall of Fame.
His current incarnation of Guns N' Roses released the long-awaited studio album Chinese Democracy in November 2008.
Watch Guns N' Roses perform 'Nightrain' below: