The second run of the FX horror drama follows a different story from its freshman season. It will take place in the 1960s at an asylum for the criminally insane run by a nun.
In the video, Jessica Lange's character Sister Jude is featured telling a patient: "Here you will repent for your sins to the only judge that matters."
The Asylum cast also includes Adam Levine, Zachary Quinto, Joseph Fiennes, James Cromwell, Jenna Dewan and Chloe Sevigny.
Prior to the trailer, the show has released many teasers on its Facebook page that hint at what fans can expect from the second season.
American Horror Story: Asylum will premiere on Wednesday, October 17 at 10pm on FX. It will air on FX UK on Tuesday, October 30 at 10pm.