The new NBC drama pilot, produced by Jerry Bruckheimer, follows three suburban couples who must face the aftermath of a murder.
Henderson will play a former flight surgeon and astronaut named Kyle Dunn, reports TVLine.
Kyle comes back to his family "after a prolonged absence and finds life with his family isn't what it seems".
The Secret Lives of Husbands and Wives already has Nicole Ari Parker and Perrey Reeves in the cast as two of the wives in the group.
Henderson starred in ABC's medical drama Off the Map, but it was cancelled after one season.
Watch a trailer for Off the Map below: