Letterman will join the Emmys host during a special week of shows broadcast from Jimmy Kimmel's birthplace of Brooklyn, broadcaster ABC has confirmed.
Comedians Chris Rock and Stephen Colbert, The Daily Show presenter Jon Stewart, daytime talkshow host Kelly Ripa and 30 Rock star Tracy Morgan have also been confirmed as special guests during the special week of shows, which will run between Monday, October 29 and Friday, November 2.
Musical performers will include Alicia Keys, Vampire Weekend, Sharon Jones and the Dap-Kings and the Avett Brothers with the Brooklyn Philharmonic.
The shows will be broadcast from the Brooklyn Academy of Music, and further guests are due to be confirmed in the coming weeks.
Jimmy Kimmel Live! airs on weeknights at midnight ET/PT on ABC.