The US President will be interviewed from the White House by MTV VJ Sway Calloway on Friday (October 26) at 5pm ET and PT.
Voters will be able to submit questions for Obama on MTV's official Facebook page.
Obama is expected to be questioned about issues facing young voters, including the economy and the President's education policy.
An MTV spokesperson said that Republican candidate Mitt Romney had been approached for a similar television special, but has not yet responded.
Obama is the midst of a whirlwind cross-country trip prior to the November 6 presidential election.
He is appearing at a Las Vegas rally with Katy Perry later today (October 24) and will be a guest on tonight's instalment of The Tonight Show with Jay Leno.