The animated comedy's latest instalment - to air tomorrow (November 7), a day after the US presidential election - predicts victory for current commander-in-chief Barack Obama.
In the episode, Eric Cartman (voiced by Trey Parker) schemes to affect the election's outcome, to the disgust of his nemesis Kyle (Matt Stone).
South Park creators Parker and Stone accurately predicted election victory for Obama once before, with season twelve episode 'About Last Night...' anticipating his triumph over John McCain in 2008.
Fellow animated comedy The Simpsons also recently satirised the election race between Obama and his rival Mitt Romney, with notorious tyrant Mr Burns endorsing the Republican candidate.
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Watch a clip from South Park's 'Obama Wins!' below: