Erinn Hayes, Anthony Anderson, Jamie-Lynn Sigler, Jesse Bradford, Zach Cregger and Tempestt Bledsoe appear in the appeal to ask for donations for the American Red Cross's clean-up efforts across the East Coast.
Anderson also sent a supportive message to all of those who lost loved ones or their homes on the storm-ravaged coast.
"From all of us here at Guys with Kids to all of our friends on the East Coast, we love you," Anderson said, with the cast echoing his final words.
Guys with Kids airs on NBC, the network that broadcast the telethon Hurricane Sandy: Coming Together featuring Bruce Springsteen, Sting and Jimmy Fallon last Friday (November 2).
Viewers ultimately donated more than $23 million (£14.4m) for the American Red Cross's ongoing relief mission in the region.
Guys with Kids airs Wednesdays at 8.30/7.30c on NBC.