The 24-year-old daughter of Bruce Willis and Demi Moore will play a potential love interest for Max (Masi Oka), according to Entertainment Weekly.
Her character Sabrina shows some interest in Max, but their flirtation is cut off when the bank she works in is held up by thieves.
Willis previously starred in ten episodes of 90210 and has also appeared on Medium, The Secret Life of the American Teenager and CSI: NY.
Other guest actors lined up for roles on Hawaii Five-0 include Star Trek's George Takei and Victoria's Secret supermodel Behati Prinsloo.
Hawaii Five-0 continues on Mondays at 10/9c in the US and airs on Sky1 in the UK.
> Hawaii Five-0 to remake classic episode, shoot prequel
> Terry O'Quinn doubts Hawaii Five-0 return: "I have no plans"
Watch a clip from Hawaii Five-0 below: