The telemovie, which features Lowe as Florida prosecutor Jeff Ashton, will screen for the first time on Saturday, January 19, 2013.
Anthony was tried for the first degree murder of her 2-year-old daughter Caylee last year, but was controversially acquitted. Virginia Welch (A God Named Pablo) will portray her in the movie.
Prosecuting Casey Anthony is told from Ashton's point of view, and is based on his book Imperfect Justice: Prosecuting Casey Anthony.
Elizabeth Mitchell (Lost, Law & Order: SVU), Oscar Nunez (The Office) Marisa Ramirez (Spartacus: Gods of the Arena) and Kevin Dunn (Transformers) are among the supporting cast.
Prosecuting Casey Anthony is produced by Fox Television Studios and a senior production team including Lowe. Peter Werner (Justified, Elementary) directed the TV movie from a screenplay by Rizzoli & Isles executive producer Alison Cross.