The Superbad actor will appear in a February episode of the Fox comedy starring The Office's Mindy Kaling, the network confirmed at the Television Critics Association's winter press tour in Pasadena.
Rogen will play Sam, the man which Mindy had her first kiss with at Jewish summer camp in 'The One That Got Away'. The episode will see the pair rekindle their teenage fling.
The episode will see Rogen reunite with Kaling, who both star in apocalyptic comedy This Is the End.
The Mindy Project will see several changes when it returns to Fox tonight (January 8).
Stephen Tobolowsky has been written out as Dr Shulman, while comedian Mary Grill has signed up to recur as Mindy's old college friend.
Beth Grant's character Nurse Beverly has also been promoted to a series regular.
Watch Seth Rogen in the trailer for This Is the End below: