The Ricki Lake Show, which premiered in September last year, has been officially cancelled by Twentieth Television.
"I am so proud of the shows we completed this season, sparking important conversations about everything from raising children to mental illness to suicide prevention to coming out," Lake said.
"I will continue to be an active and passionate voice for subjects that are close to my heart through a variety of platforms - and a return to my documentary filmmaking work with Abby Epstein.
"I am excited to create meaningful and provocative films similar to our 2007 project The Business of Being Born."
Stephen Brown, executive vice president of programming and development at Twentieth Television, explained that while "we are all proud of the topics the programme tackled", the show wasn't "able to break through the crowded talk show marketplace".
Lake, who hosted a popular talk show from 1994 to 2004, faced much competition this time round from the likes of Katie Couric, whose talk show Katie was recently renewed for a second season by Disney-ABC Domestic Television.