The actress will play a woman named Karen who wakes up from a coma to discover that she has a teenage daughter, according to The Hollywood Reporter.
Ricci is said to be finalising the terms of her deal for the show, which will be produced by Universal Television and Wolf Films.
Nurse Jackie creator Liz Brixius and Law & Order: SVU's Dick Wolf are behind the comedy.
Girlfriend in a Coma centres around Karen waking up after almost two decades to find out that she has a 17-year-old daughter from a pregnancy she was unaware of when she entered her coma.
Brixius will write the script for the single-camera comedy and will serve as executive producer alongside Wolf, Danielle Gelber and Peter Jankowski.
Ricci, who recently announced her engagement to boyfriend James Heerdegen, guest starred on CBS's The Good Wife last year.
The role came after her stint on ABC's short-lived series Pan Am as a flight attendant.