The QI presenter will star alongside Harry Potter actor Rupert Grint as his butler Randolph.
Super Clyde is the story of a fast food worker (Grint) who decides to become a superhero after inheriting a $100,000-a-month inheritance from his long-dead eccentric uncle.
The show - from Raising Hope creator Greg Garcia - would be the television series debut for Grint, but is still currently in pilot stage and in contention for a series pick-up at CBS.
It was previously reported that Animal Practice star Tyler Labine will star as Grint's older brother.
Grint's character, Clyde, is described as "a well-meaning and sweet yet slightly neurotic guy who never feels like he really fits in".
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