MRC will provide a block of shows, including two new comedies and two new dramas, details of which have not yet been announced.
The CW said the deal, which will take effect from the autumn, would allow it to focus on shows for weekday primetime slots.
"This is a strategic move by The CW that will give viewers more original programming on Sunday nights than we have ever had," said CW entertainment president Dawn Ostroff. "As the leading independent producer of television programming, MRC will bring a slate of high-quality entertainment to our air on the most competitive night on television, while we will focus our resources and efforts on strengthening our Monday through Friday schedule."
Keith Samples, television president for MRC, added: "Our blend of comedy and drama will be exciting, accessible and a perfect fit for the network and its affiliate constituency."