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The actor, who plays Dr. Jack Shephard in the cult drama, revealed that he knows what the "final image" of the series will be.
Asked if that meant that he was aware of a single image, he replied: "Yes. I literally just know that final image."
"I don't think the word 'Lost' will come up at the end of the last [episode]," he told Digital Spy. "That's how much finality it will have. Unlike any other episode ever done on Lost, I think it will just go to black and that will be it."
On rumours of a spinoff show, Fox added: "I think the show will end in a way that there really cannot be any future of Lost. That would be my guess."
Lost returns for its sixth and final season in early 2010.
> Click here to watch our interview with Matthew Fox in full
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