E! Online reports that O'Quinn - who played John Locke on the show - will star alongside Oscar-nominated actress Taraji P. Henson in the Lifetime television movie Taken From Me: The Tiffany Rubin Story.
The project will tell the story of Tiffany Rubin (Henson), a desperate mother forced to rescue her young son when he is kidnapped and taken to Korea by his father.
In the film, O'Quinn will play Mark Miller, the head of charitable organisation The American Association for Lost Children, who helps Rubin travel to Korea to save her son.
Production on the film will begin next month in Vancouver.