The former Friends star, who returns to TV screens in Mr Sunshine tonight, told ABC's Jimmy Kimmel Live that he had been a "huge fanatic" of the drama, which wrapped following its sixth season last year.
"I miss it," he said on Tuesday's show, "I was just about to say I'm lost without it! I really don't know what to do with myself now that it's not on. That was my favourite thing in the history of entertainment."
He went on to joke about an incident that happened between himself and Mr Sunshine co-star Jorge Garcia, who previously starred as Hurley in Lost.
"I was on a show that he saw, and he was on a show that I saw so there was a mutual respect," he explained. "We didn't really talk about it. It was just, 'Nice to meet you... You'll stand here'. But in the third episode he did something that was really funny and I said, 'That was really funny dude!' I realised I'd done his catchphrase to him and was like, 'Oh God, I'm so sorry!'"
Perry said back in 2009 that he was eager to land a role on Lost but acknowledged that his fame from Friends might make a possible appearance unrealistic.
Mr Sunshine premieres tonight at 9.30pm on ABC.