Perrineau's character Michael was known for his over-protective nature towards son Walt (Malcolm David Kelley) and for shouting the boy's name when he went missing.
"I'm surprised, honestly - every day there's at least five people who only say 'Waaaaalt!'" the actor told TV Guide.
"That's all they say. It's always surprising, like, again, today?"
Perrineau appeared regularly on Lost between 2004 and 2006 and returned for guest stints in 2008 and 2010.
The 49-year-old actor will next be seen in the new season of FX biker drama Sons of Anarchy and in TBS comedy The Wedding Band.
Lost co-creator Damon Lindelof suggested in May that the series will eventually return in some form.
"I do feel like the world has not seen the end of Lost but I'm not going to have any involvement," he said.
> Revolution, The Event, Alcatraz - the quest for the new Lost
Watch clips of Harold Perrineau on Lost below: