Family Guide follows Henry (Eli Barker) who looks up to his blind father (JK Simmons), and is bewildered by his mother's Mel (Parker Posey) late adolescence after his parents' divorce, reports Deadline.
Henry is befriended by Perrineau's character, who is the manager of Mel's new apartment building.
Family Guide is directed by David Schwimmer, with Jason Bateman serving as an executive producer along with Nash, who wrote the pilot.
Perrineau is best known for his role on ABC's drama Lost. He has also previously appeared on Sons of Anarchy, The Wedding Band and Law & Order: Special Victims Unit.
Perrineau also recently starred in the Oscar-nominated Zero Dark Thirty.
Watch a trailer for Zero Dark Thirty below: