The 41-year-old, who played Dylan McKay in the '90s TV show, said he has no plans to reprise the role.
Former co-stars Tori Spelling and Jennie Garth have joined the cast of CW series 90210, while Jason Priestley and Ian Ziering have also expressed an interest.
However, Perry ruled out the possibility of making a return, telling The Billy Bush Show: "I can't re-imagine it currently. It's just not something that I've thought about to be quite honest, I don't see it happening.
"I wish them a lot of luck. I hope they have a lot of success with it."