The 'Dynamite' singer will feature in the CW teen drama's 100th episode, according to TVLine.
Cruz will be seen performing at a West Beverly High School alumni homecoming event thrown at the Playboy Mansion.
The 27-year-old's most recent musical effort was third album TY.O, which was first released in Germany in December 2011, with a US and UK release date still to be confirmed.
Denise Richards and Carmen Electra will also appear in 90210's landmark 100th episode, which will air on November 26.
The show's fifth season debuts in the US on Monday, October 8. In the UK, 90210 airs on E4.
> Ne-Yo to appear in 90210 season five
> 'Call Me Maybe' singer Carly Rae Jepsen to guest star on 90210
Watch Taio Cruz's recent interview with Digital Spy below: