The actor played Brandon Walsh in the original show for eight years and directed 15 episodes.
However, he said he has not been approached for a role in the CW production, telling Momlogic.com: "They haven't contacted me about doing anything yet. But if it's the right thing, I'm certainly open to it.
"I loved working on that show. I loved everything I did on that show. I had so many jobs on that show, I loved it so."
The 38-year-old recently starred in Lifetime's comedy-drama Side Order of Life, which was cancelled last month.
Tori Spelling has also expressed an interest in appearing in the pilot, while creator Rob Thomas reportedly wants Jennie Garth to return as Kelly Taylor.
Lori Loughlin and Shenae Grimes have so far been confirmed on the cast.