The actor - who plays Seeley Booth - indicated on Twitter that the Fox drama's eighth season could be its last.
Referencing the Bones cast's appearance at this year's San Diego Comic-Con, he wrote: "SDCC 2012 shld be a blast and quite possibly the last for Bones? Farewell tour? Look forward to seeing everyone there."
He later added: "Let's put this in sports terms. I'm a free agent after this season. So the Bones fair well tour is in full-swing.
"You must always keep your options open and ready for new challenges. The fear is the unknown and that's exciting."
Bones was officially renewed for an eighth season in March. The show's creator Hart Hanson previously claimed that a ninth run was also a strong possibility.
Series exec Stephen Nathan has also claimed that the show's supporting characters will get more screentime next season.
"We weren't able to give some of the other characters that we love – Hodgins (TJ Thyne) and Cam (Tamara Taylor) – more extensive arcs [this year]," he said. "[Plus] more Booth family stuff."
Bones will return to Monday nights at 8pm this fall on Fox.
> Bones exec: 'Brennan, Booth are phenomenal couple'
Watch a clip from the Bones season seven finale below: