In the Fox drama's recent season finale, Peter Bishop (Jackson) was erased from history by a time paradox.
Discussing the cliffhanger, the actor told Entertainment Weekly: "It's radical. It could wipe clean the entire slate of Fringe."
Jackson claimed that Peter's disappearance could put an end to the character's blossoming romance with Olivia (Anna Torv).
"[Romance] is inevitable when you have a man and a woman in leading roles on a TV show, but I do feel it was a distraction from the central story of the show," he said. "I feel the romantic portion of this show is now over so we can spend more time being Fringe again."
He also admitted that some plot threads, such as Peter's secret child with Olivia's doppelganger Fauxlivia, may not need to be resolved, given the character's current status.
"We bought ourselves the ability to not pay those things off without cheating the audience," he claimed. "It's genius."
Fringe producers Jeff Pinkner and Joel Wyman recently insisted that Jackson will return to the series next season, despite the apparent loss of Peter.
The show's third season concluded last Friday on Fox. A fourth season will premiere in the fall.
Watch the stars of Fringe discuss the show's future below: