Showrunners Jeff Pinkner and Joel Wyman recently claimed that the season premiere will be "like a new pilot" for a first-time audience.
Noble, who plays Walter Bishop on the sci-fi drama, told Blastr: "We have a mythology now that needs to be unraveled a little bit for new viewers. I defy people to come in at the end of season three and understand [what's going on]. They might find it really interesting, but to understand it might be hard."
The actor added that the Fringe writing team might "give [the show] a restart" following the disappearance of Peter (Joshua Jackson).
"We need to unravel some of that mythology a bit, and I think that might be what they mean," he suggested. "Give it a restart, from the same place, but for example without Peter."
Noble claimed that the new season could examine familiar events "from a slightly different angle".
"We have to retell some of the story," he argued. "I'm sure that [the writers] mean retelling the story again, but from a slightly different angle. I'll wait and see when I get the first script."
Fringe will return to Fridays at 9/8c on Fox.
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