Fox entertainment president Kevin Reilly recently revealed that the sci-fi drama is losing money for Fox on Friday nights.
Jackson told IGN: "I think Kevin was being pretty honest. If we're not making them money on Friday then that show is going to get cancelled. Whether it's Fringe or American Idol, when it stops making money, you know, it's show business."
He continued: "Whether [the show ends] this year, whether we get a half-season next year, whether we get a whole season next year, whether we run for ten more years, at the end of the day... what will be important is not how long it runs but if the whole story finishes. So I'm more concerned about the finish than anything else."
Jackson previously insisted that Fringe deserves a real ending, calling on Fox to give the show's writing team enough time to reach a suitable conclusion.
"I just want to take Kevin Reilly's word that if they are going to end it this year, that they give the guys enough of a heads-up [to] get that whole endgame out," he reiterated.
"Because at this point, the most important thing to me - and this is so maudlin - but the most important thing to me about Fringe is that it finishes properly. Because you can't bring people along a journey like that for all those years and then just cut it off. It sucks."
He concluded: "That would really bum me out at the end of what's been a pretty cool experience, to not have the finish."
Fringe continues on Fridays at 9/8c on Fox. Sky1 airs the show in the UK.
> Fringe: 'Enemy of my Enemy' in pictures
> Fringe: 'Back to Where You've Never Been' recap
Watch a clip from the next episode of Fringe below: