Kirkman has already confirmed that much of the season will take place at a farm owned by new character Hershel (Scott Wilson).
"They're heading to the farm, it's going to be awesome," Kirkman told The Hollywood Reporter.
"The first season was all about being in the city, and dealing with zombies in the streets. The second season is about zombies in the woods and what's behind that next tree. It's a much more rural setting."
Kirkman continued: "It's all the same characters, and they're going to be dealing with a lot of plots from the first season, but the setting is going to be almost completely different. I didn't realise how cool it would be until I was on set, running through the woods doing location scouting a couple of weeks ago. Atlanta was almost a character in the first season, and I think it will be that way with Georgia in general in this upcoming season."
Kirkman has previously confirmed that the mystery of Jenner's whisper wll be resolved, while his colleague Frank Darabont has suggested that the new season is about "conflict".
The Walking Dead will return on AMC in the US and on FX in the UK later this year.
Watch a behind the scenes feature for the second season of The Walking Dead below: