It was previously confirmed that the zombie drama's second run will see Rick (Andrew Lincoln) and the other survivors arrive at Hershel's farm.
"What's been surprising is that in the graphic novel, the story that takes place on Hershel's farm is really only a few issues," Mazzara told the official AMC blog. "We've been able to mine that for many episodes, and we're very excited about the depth to which we're able to push the characters [and] the different dynamics that we're able to explore."
Mazzara, who recently replaced Frank Darabont as showrunner, also revealed that the human survivors will become "a plague unto themselves" in future episodes.
"Nothing goes right for Hershel once Rick and his band show up," he explained. "They make the zombie apocalypse look like kids in a candy store."
He added that viewers may end up siding with Hershel (Scott Wilson) rather than Rick and his group.
"What's interesting is that if this was a show solely about Hershel, Rick and his band would really be the antagonists," he suggested. "That's been really surprising because every action that Rick and his band take is completely logical, but you'll certainly sympathise with Hershel."
The Walking Dead will return to AMC in the US and FX in the UK in October.
> Walking Dead star: 'Show has not suffered from Frank Darabont exit'
Watch a trailer for season two of The Walking Dead below: