Finalists Melanie Amaro, Josh Krajcik and Chris Rene will take to the stage on Wednesday night in the hope of walking away with a $5 million recording contract.
US Weekly reports that 30-year-old Krajcik, who is being mentored by Nicole Scherzinger in the Over 30s category, will sing with Alanis Morissette.
Meanwhile Simon Cowell's final singer from the Girls category, Amaro, will team up with R Kelly.
Rene, who has flourished under the mentoring of LA Reid, will also perform alongside Avril Lavigne during the broadcast.
Cowell has promised that the X Factor USA finale will showcase the "greatest talent" possible.
Digital Spy readers have predicted that Melanie Amaro will win the competition during Thursday night's finale.
> Simon Cowell has 'a few tricks up his sleeves' for 'X Factor' USA
Watch the video for Alanis Morissette's 'Ironic' below: