The rapper confirmed on his official Twitter page that he will take the stage during Thursday night's broadcast, rounding out the roster of big name artists.
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Justin Bieber, Leona Lewis and Stevie Wonder are also scheduled to appear, along with Pitbull and Ne-Yo.
Finalists Melanie Amaro, Josh Krajcik and Chris Rene performed twice during Wednesday night's broadcast, with each duetting with R Kelly, Alanis Morissette and Avril Lavigne respectively.
Show boss and judge Simon Cowell recently hinted that he has "a few tricks up his sleeves" for The X Factor USA, adding that the show will undergo changes for next season.
The X Factor USA opened online auditions for its second season earlier this month.
> Melanie Amaro 'X Factor' USA win predicted by Digital Spy readers
Watch the video to 50 Cent's breakthrough hit 'In Da Club' below:
